RETRACTED: A Mechanochemical Approach to Deracemization (Retracted Article)

被引：32

作者：

Wiggins, Kelly M. ^{[1
]}

Bielawski, Christopher W. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Univ Stn 1, Austin, TX 78712 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 07期

关键词：

atropisomerism; chiral resolution; mechanochemistry; polymers; ultrasound; ASYMMETRIC TRANSFORMATIONS; ENZYMES; RESOLUTIONS; CATALYSIS; POLYMERS;

D O I：

10.1002/anie.201107937

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Good combination: Enantioselective enzymatic hydrolysis was combined with a mechanically facilitated racemization process to prepare (S)-1,1′- binapthol ((S)-binol) in high yield and enantiopurity from a racemic precursor in a single step (see scheme). The enzyme cholesterol esterase stereoselectively hydrolyzes esters of (S)-binol and ultrasound was applied to achieve mechanically facilitated racemization of the precursor material. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1640 / 1643

页数：4

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