Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury

被引：1

作者：

Cheng, Fafeng ^{[1
]}

Song, Wenting ^{[2
]}

Zhong, Xianggen ^{[1
]}

Lu, Yi ^{[1
]}

Guo, Shaoying ^{[1
]}

Wang, Dong ^{[1
]}

Zhao, Weipeng ^{[1
]}

Wang, Qingguo ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Coll Basic Med, Beijing 100029, Peoples R China

[2] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 21期

关键词：

focal cerebral ischemia; Qingkailing injection; time window; infarct volume; neurological function; anti-oxidation; ISCHEMIA-REPERFUSION INJURY; NMDA RECEPTOR ACTIVATION; NITRIC-OXIDE SYNTHASE; SUPEROXIDE-DISMUTASE; NADPH OXIDASE; TIME WINDOW; LIPID-PEROXIDATION; ARTERY OCCLUSION; ANGIOTENSIN-II; BRAIN-DAMAGE;

D O I：

10.3969/j.issn.1673-5374.2011.21.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing (1.5, 3, 6 mL/kg). Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice.

引用

页码：1605 / 1611

页数：7

共 42 条

[1] Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions [J].

Aarts, M ;

Liu, YT ;

Liu, LD ;

Besshoh, S ;

Arundine, M ;

Gurd, JW ;

Wang, YT ;

Salter, MW ;

Tymianski, M .

SCIENCE, 2002, 298 (5594) :846-850

[2] Neonatal Stroke in Mice Causes Long-Term Changes in Neuronal Notch-2 Expression That May Contribute to Prolonged Injury [J].

Alberi, Lavinia ;

Chi, Zhikai ;

Kadam, Shilpa D. ;

Mulholland, Justin D. ;

Dawson, Valina L. ;

Gaiano, Nicholas ;

Comi, Anne M. .

STROKE, 2010, 41 (10) :S64-S71

[3]

[Anonymous], 2005, ADM DIV PEOPL REP CH

[4]

*BEIJ U CHIN MED, 1975, XINYIYAO XUE ZAZHI, P12

[5]

Bindokas VP, 1996, J NEUROSCI, V16, P1324

[6] Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha 1-syntrophin mediated by PDZ domains [J].

Brenman, JE ;

Chao, DS ;

Gee, SH ;

McGee, AW ;

Craven, SE ;

Santillano, DR ;

Wu, ZQ ;

Huang, F ;

Xia, HH ;

Peters, MF ;

Froehner, SC ;

Bredt, DS .

CELL, 1996, 84 (05) :757-767

[7] NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation [J].

Brennan, Angela M. ;

Suh, Sang Won ;

Won, Seok Joon ;

Narasimhan, Purnima ;

Kauppinen, Tiina M. ;

Lee, Hokyou ;

Edling, Ylva ;

Chan, Pak H. ;

Swanson, Raymond A. .

NATURE NEUROSCIENCE, 2009, 12 (07) :857-U57

[8] 2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window [J].

Capone, Carmen ;

Fabrizi, Cinzia ;

Piovesan, Paola ;

Principato, Maria Cristina ;

Marzorati, Patrizia ;

Ghirardi, Orlando ;

Fumagalli, Lorenzo ;

Carminati, Paolo ;

De Simoni, Maria Grazia .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (06) :1302-1311

[9] Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function [J].

Chen, X ;

Howard, OMZ ;

Yang, XY ;

Wang, LH ;

Oppenheim, JJ ;

Krakauer, T .

LIFE SCIENCES, 2002, 70 (24) :2897-2913

[10]

CHENG FF, 2011, ZHONGYAO YAOLI YU LI, V27, P106

← 1 2 3 4 5 →