Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury

被引：1

作者：

Cheng, Fafeng ^{[1
]}

Song, Wenting ^{[2
]}

Zhong, Xianggen ^{[1
]}

Lu, Yi ^{[1
]}

Guo, Shaoying ^{[1
]}

Wang, Dong ^{[1
]}

Zhao, Weipeng ^{[1
]}

Wang, Qingguo ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Coll Basic Med, Beijing 100029, Peoples R China

[2] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 21期

关键词：

focal cerebral ischemia; Qingkailing injection; time window; infarct volume; neurological function; anti-oxidation; ISCHEMIA-REPERFUSION INJURY; NMDA RECEPTOR ACTIVATION; NITRIC-OXIDE SYNTHASE; SUPEROXIDE-DISMUTASE; NADPH OXIDASE; TIME WINDOW; LIPID-PEROXIDATION; ARTERY OCCLUSION; ANGIOTENSIN-II; BRAIN-DAMAGE;

D O I：

10.3969/j.issn.1673-5374.2011.21.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing (1.5, 3, 6 mL/kg). Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice.

引用

页码：1605 / 1611

页数：7

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