Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes

被引：97

作者：

Chi, Ya-Hui ^{[1
]}

Haller, Kerstin ^{[1
]}

Peloponese, Jean-Marie, Jr. ^{[1
]}

Jeang, Kuan-Teh ^{[1
]}

机构：

[1] NIAID, NIH, Mol Microbiol Lab, Mol Virol Sect, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2007年 / 282卷 / 37期

关键词：

D O I：

10.1074/jbc.M703098200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Replicated mammalian chromosomes condense to segregate during anaphase, and they de-condense at the conclusion of mitosis. Currently, it is not understood what the factors and events are that specify de-condensation. Here, we demonstrate that chromosome de-condensation needs the function of an inner nuclear membrane (INM) protein hsSUN1 and a membrane-associated histone acetyltransferase ( HAT), hALP. We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis.

引用

页码：27447 / 27458

页数：12

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