Precursors to pancreatic cancer

被引：156

作者：

Hruban, Ralph H. ^{[1
,2
]}

Maitra, Anirban ^{[1
,2
]}

Kern, Scott E. ^{[1
,2
,3
]}

Goggins, Michael ^{[1
,2
,4
]}

机构：

[1] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Inst Genet Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Gastroenterol, Baltimore, MD 21205 USA

来源：

GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2007年 / 36卷 / 04期

关键词：

D O I：

10.1016/j.gtc.2007.08.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Infiltrating ductal adenocarcinoma of the pancreas is believed to arise from morphologically distinct noninvasive precursor lesions. These precursors include the intraductal papillary mucinous neoplasm, the mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Intraductal. papillary mucinous neoplasms are grossly visible mucin-producing epithelial neoplasms that arise in the main pancreatic duct or one of its branches. The cysts of mucinous cystic neoplasms do not communicate with the major pancreatic ducts, and these neoplasms are characterized by a distinct ovarian-type stroma. Pancreatic intraepithelial neoplasia is a microscopic lesion. The is article focuses on the clinical significance of these three important precursor lesions, with emphasis on their clinical manifestations, detection, and treatment.

引用

页码：831 / +

页数：20

共 106 条

[1] Colloid (mucinous noncystic) carcinoma of the pancreas [J].

Adsay, NV ;

Pierson, C ;

Sarkar, F ;

Abrams, J ;

Weaver, D ;

Conlon, KC ;

Brennan, MF ;

Klimstra, DS .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (01) :26-42

[2] Intraductal oncocytic papillary neoplasms of the pancreas [J].

Adsay, NV ;

Adair, CF ;

Heffess, CS ;

Klimstra, DS .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (08) :980-994

[3]

ADSAY NV, 1997, MODERN PATHOL, V10, pA143

[4] Neoplasms of the ampulla of Vater with concurrent pancreatic intraductal neoplasia: A histological and molecular study [J].

Agoff, SN ;

Crispin, DA ;

Bronner, MP ;

Dail, DH ;

Hawes, SE ;

Haggitt, RC .

MODERN PATHOLOGY, 2001, 14 (03) :139-146

[5] MUCINOUS CYSTADENOCARCINOMA OF THE PANCREAS - MORPHOLOGICAL AND IMMUNOCYTOCHEMICAL OBSERVATIONS [J].

ALBORESSAAVEDRA, J ;

ANGELESANGELES, A ;

NADJI, M ;

HENSON, DE ;

ALVAREZ, L .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1987, 11 (01) :11-20

[6] A selective approach to the resection of cystic lesions of the pancreas - Results from 539 consecutive patients [J].

Allen, Peter J. ;

D'Angelica, Michael ;

Gonen, Mithat ;

Jaques, David P. ;

Coit, Daniel G. ;

Jarnagin, William R. ;

DeMatteo, Ronald ;

Fong, Yuman ;

Blumgart, Leslie H. ;

Brennan, Murray F. .

ANNALS OF SURGERY, 2006, 244 (04) :572-582

[7]

*AM CANC SOC, 2007, CANC FACTS FIG 2007, P1

[8] Cancer as a complex phenotype: Pattern of cancer distribution within and beyond the nuclear family [J].

Amundadottir, LT ;

Thorvaldsson, S ;

Gudbjartsson, DF ;

Sulem, P ;

Kristjansson, K ;

Arnason, S ;

Gulcher, JR ;

Bjornsson, J ;

Kong, A ;

Thorsteinsdottir, U ;

Stefansson, K .

PLOS MEDICINE, 2004, 1 (03) :229-236

[9] Clinicopathological correlates of pancreatic intraepithelial neoplasia: A comparative analysis of 82 cases with and 152 cases without pancreatic ductal adenocarcinoma [J].

Andea, A ;

Sarkar, F ;

Adsay, VN .

MODERN PATHOLOGY, 2003, 16 (10) :996-1006

[10] The role of pancreatoscopy in the preoperative evaluation of intraductal papillary mucinous tumor of the pancreas [J].

Atia, GN ;

Brown, RD ;

Alrashid, A ;

Halline, AG ;

Helton, WS ;

Venu, RP .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2002, 35 (02) :175-179

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