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Precursors to pancreatic cancer

被引：156
作者：
Hruban, Ralph H. [1 ,2 ]
Maitra, Anirban [1 ,2 ]
Kern, Scott E. [1 ,2 ,3 ]
Goggins, Michael [1 ,2 ,4 ]
机构：
[1] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Oncol, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Inst Genet Med, Baltimore, MD 21205 USA
[4] Johns Hopkins Med Inst, Sol Goldman Pancreat Canc Res Ctr, Dept Gastroenterol, Baltimore, MD 21205 USA
来源：
GASTROENTEROLOGY CLINICS OF NORTH AMERICA | 2007年 / 36卷 / 04期
关键词：
D O I：
10.1016/j.gtc.2007.08.012
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Infiltrating ductal adenocarcinoma of the pancreas is believed to arise from morphologically distinct noninvasive precursor lesions. These precursors include the intraductal papillary mucinous neoplasm, the mucinous cystic neoplasm, and pancreatic intraepithelial neoplasia. Intraductal. papillary mucinous neoplasms are grossly visible mucin-producing epithelial neoplasms that arise in the main pancreatic duct or one of its branches. The cysts of mucinous cystic neoplasms do not communicate with the major pancreatic ducts, and these neoplasms are characterized by a distinct ovarian-type stroma. Pancreatic intraepithelial neoplasia is a microscopic lesion. The is article focuses on the clinical significance of these three important precursor lesions, with emphasis on their clinical manifestations, detection, and treatment.
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页码：831 / +
页数：20
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