MED1: A central molecule for maintenance of genome integrity and response to DNA damage

被引：22

作者：

Parsons, BL ^{[1
]}

机构：

[1] US FDA, Natl Ctr Toxicol Res, Div Genet & Reprod Toxicol, Jefferson, AR 72079 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 25期

关键词：

D O I：

10.1073/pnas.2637169100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：14601 / 14602

页数：2

共 17 条

[1] MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1 [J].

Bellacosa, A ;

Cicchillitti, L ;

Schepis, F ;

Riccio, A ;

Yeung, AT ;

Matsumoto, Y ;

Golemis, EA ;

Genuardi, M ;

Neri, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3969-3974

[2] Functional interactions and signaling properties of mammalian DNA mismatch repair proteins [J].

Bellacosa, A .

CELL DEATH AND DIFFERENTIATION, 2001, 8 (11) :1076-1092

[3] DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis [J].

Bernstein, C ;

Bernstein, H ;

Payne, CM ;

Garewal, H .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2002, 511 (02) :145-178

[4] The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity [J].

Cortellino, S ;

Turner, D ;

Masciullo, V ;

Schepis, F ;

Albino, D ;

Daniel, R ;

Skalka, AM ;

Meropol, NJ ;

Alberti, C ;

Larue, L ;

Bellacosa, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :15071-15076

[5] Pms2 deficiency results in increased mutation in the Hprt gene but not the Tk gene of Tk± transgenic mice [J].

Dobrovolsky, VN ;

McKinzie, PB ;

Shaddock, JG ;

Mittelstaedt, RA ;

Heflich, RH ;

Parsons, BL .

MUTAGENESIS, 2003, 18 (04) :365-370

[6] Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites [J].

Drummond, JT ;

Bellacosa, A .

NUCLEIC ACIDS RESEARCH, 2001, 29 (11) :2234-2243

[7] DNA repair and tumorigenesis - Lessons from hereditary cancer syndromes [J].

Heinen, CD ;

Schmutte, H ;

Fishel, R .

CANCER BIOLOGY & THERAPY, 2002, 1 (05) :477-485

[8] Identification and characterization of a family of mammalian methyl-CpG binding proteins [J].

Hendrich, B ;

Bird, A .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6538-6547

[9] The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites [J].

Hendrich, B ;

Hardeland, U ;

Ng, HH ;

Jiricny, J ;

Bird, A .

NATURE, 1999, 401 (6750) :301-304

[10] Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice [J].

Millar, CB ;

Guy, J ;

Sansom, OJ ;

Selfridge, J ;

MacDougall, E ;

Hendrich, B ;

Keightley, PD ;

Bishop, SM ;

Clarke, AR ;

Bird, A .

SCIENCE, 2002, 297 (5580) :403-405

← 1 2 →