Wall shear stress in the development of in-stent restenosis revisited. A critical review of clinical data on shear stress after intracoronary stent implantation

被引:30
作者
Jenei, Csaba [1 ]
Balogh, Emilia [1 ]
Szabo, Gabor Tamas [1 ]
Dezsi, Csaba Andras [2 ]
Koszegi, Zsolt [1 ]
机构
[1] Univ Debrecen, Inst Cardiol, Debrecen, Hungary
[2] Petz Aladar Cty Teaching Hosp, Dept Cardiol, Vasvari P Str 2-4, H-9024 Gyor, Hungary
关键词
wall shear stress; percutaneous coronary intervention; stent implantation; in-stent restenosis; CORONARY-ARTERY-DISEASE; SMOOTH-MUSCLE-CELLS; VASCULAR SCAFFOLD IMPLANTATION; OPTICAL COHERENCE TOMOGRAPHY; NEOINTIMAL HYPERPLASIA; BIFURCATION LESIONS; ELUTING STENTS; FOLLOW-UP; ATHEROSCLEROSIS; PLAQUE;
D O I
10.5603/CJ.a2016.0047
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
The average wall shear stress (WSS) is in 1 Pa range in coronary arteries, while the stretching effect of an implanted coronary stent can generate up to 3 x 10(5) times higher circumferential stress in the vessel wall. It is widely accepted that WSS plays a critical role in the development of restenosis after coronary stent implantation, but relevant clinical endpoint studies are lacking. Fluid dynamics modeling suggests an association between WSS and intimal hyperplasia, however, such an association is not established when the compensating healing process becomes an overshoot phenomenon. This review summarizes available clinical results and concepts of potential clinical importance.
引用
收藏
页码:365 / 373
页数:9
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