Immunotherapeutic gene transfer into muscle

被引：43

作者：

Prud'homme, GJ

Lawson, BR

Chang, YG

Theofilopoulos, AN

机构：

[1] McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 03期

关键词：

D O I：

10.1016/S1471-4906(00)01822-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases and is relevant to the development of effective DNA vaccines in autoimmune diseases, infectious diseases and cancer.

引用

收藏

页码：149 / 155

页数：7

相关论文

共 61 条

[1] DNA vaccination with full-length or truncated Neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice [J].

Amici, A ;

Smorlesi, A ;

Noce, G ;

Santoni, G ;

Cappelletti, P ;

Capparuccia, L ;

Coppari, R ;

Lucciarini, R ;

Petrelli, C ;

Provinciali, M .

GENE THERAPY, 2000, 7 (08) :703-706

[2] Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice [J].

Balomenos, D ;

Rumold, R ;

Theofilopoulos, AN .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :364-371

[3] Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia [J].

Baumgartner, I ;

Pieczek, A ;

Manor, O ;

Blair, R ;

Kearney, M ;

Walsh, K ;

Isner, JM .

CIRCULATION, 1998, 97 (12) :1114-1123

[4] Interactions between the immune system and gene therapy vectors: Bidirectional regulation of response and expression [J].

Bromberg, JS ;

Debruyne, LA ;

Qin, LH .

ADVANCES IN IMMUNOLOGY, VOL 69, 1998, 69 :353-409

[5]

Calarota SA, 1999, J IMMUNOL, V163, P2330

[6] Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope [J].

Casares, S ;

Inaba, K ;

Brumeanu, TD ;

Steinman, RM ;

Bona, CA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) :1481-1486

[7]

Chang YG, 1999, J GENE MED, V1, P415, DOI 10.1002/(SICI)1521-2254(199911/12)1:6<415::AID-JGM66>3.0.CO

[8]

2-B

[9]

Chattergoon MA, 1998, J IMMUNOL, V160, P5707

[10] Modulating the immune response to genetic immunization [J].

Cohen, AD ;

Boyer, JD ;

Weiner, DB .

FASEB JOURNAL, 1998, 12 (15) :1611-1626

← 1 2 3 4 5 6 7 →