Immunotherapeutic gene transfer into muscle

被引：43

作者：

Prud'homme, GJ

Lawson, BR

Chang, YG

Theofilopoulos, AN

机构：

[1] McGill Univ, Dept Pathol, Montreal, PQ H3A 2B4, Canada

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 03期

关键词：

D O I：

10.1016/S1471-4906(00)01822-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases and is relevant to the development of effective DNA vaccines in autoimmune diseases, infectious diseases and cancer.

引用

收藏

页码：149 / 155

页数：7

相关论文

共 61 条

[51] MODULATION OF DISEASE-ACTIVITY IN MURINE SYSTEMIC LUPUS-ERYTHEMATOSUS BY CYTOKINE GENE DELIVERY [J].

RAZ, E ;

DUDLER, J ;

LOTZ, M ;

BAIRD, SM ;

BERRY, CC ;

EISENBERG, RA ;

CARSON, DA .

LUPUS, 1995, 4 (04) :286-292

[52] The application of gene therapy in autoimmune diseases [J].

Seroogy, CM ;

Fathman, CG .

GENE THERAPY, 2000, 7 (01) :9-13

[53] IL-12 plasmid-enhanced DNA vaccination against carcinoembryonic antigen (CEA) studied in immune-gene knockout mice [J].

Song, K ;

Chang, Y ;

Prud'homme, GJ .

GENE THERAPY, 2000, 7 (18) :1527-1535

[54] Regulation of T-helper-1 versus T-helper-2 activity and enhancement of tumor immunity by combined DNA-based vaccination and nonviral cytokine gene transfer [J].

Song, K ;

Chang, Y ;

Prud'homme, GJ .

GENE THERAPY, 2000, 7 (06) :481-492

[55] Plasmid DNA encoding transforming growth factor-β1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model [J].

Song, XY ;

Gu, ML ;

Jin, WW ;

Klinman, DM ;

Wahl, SM .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) :2615-2621

[56] Tumour necrosis factor and other cytokines in murine lupus [J].

Theofilopoulos, AN ;

Lawson, BR .

ANNALS OF THE RHEUMATIC DISEASES, 1999, 58 :49-55

[57]

Torres CAT, 1997, J IMMUNOL, V158, P4529

[58] Generation of MHC class I-restricted cytotoxic T lymphocytes by expression of a viral protein in muscle cells: Antigen presentation by non-muscle cells [J].

Ulmer, JB ;

Deck, RR ;

Dewitt, CM ;

Donnelly, JJ ;

Liu, MA .

IMMUNOLOGY, 1996, 89 (01) :59-67

[59] Increased DNA vaccine delivery and immunogenicity by electroporation in vivo [J].

Widera, G ;

Austin, M ;

Rabussay, D ;

Goldbeck, C ;

Barnett, SW ;

Chen, MC ;

Leung, L ;

Otten, GR ;

Thudium, K ;

Selby, MJ ;

Ulmer, JB .

JOURNAL OF IMMUNOLOGY, 2000, 164 (09) :4635-4640

[60]

WOLFF JA, 1995, GENE THERAPEUTICS, P82

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