A new and convergent synthesis of (2S)-7-(4,4′-bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid using a palladium-catalysed aminocarbonylation reaction

被引：11

作者：

Etridge, SK ^{[1
]}

Hayes, JF ^{[1
]}

Walsgrove, TC ^{[1
]}

Wells, AS ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Tonbridge TN11 9AN, Kent, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1999年 / 3卷 / 01期

关键词：

D O I：

10.1021/op980068n

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Palladium-catalysed aminocarbonylation of a 7-bromo- or 7-iodo-1,4-benzodiazepine with N-Cbz-4,4'-bipiperidine hydrochloride efficiently introduced the 7-(4,4'-bipiperidinylcarbonyl) moiety of (2S)-7-(4,4'-bipiperidinylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid.

引用

页码：60 / 63

页数：4

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