Enantiospecific synthesis of SB 214857, a potent, orally active, nonpeptide fibrinogen receptor antagonist

被引：44

作者：

Miller, WH

Ku, TW

Ali, FE

Bondinell, WE

Calvo, RR

Davis, LD

Erhard, KF

Hall, LB

Huffman, WF

Keenan, RM

Kwon, C

Newlander, KA

Ross, ST

Samanen, JM

Takata, DT

Yuan, CK

机构：

[1] Department of Medicinal Chemistry, SmithKline Beecham Pharmaceutical, 709 Swedeland Road. P.O. Box 1539, King of Prussia

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 52期

关键词：

D O I：

10.1016/0040-4039(95)02054-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiospecific synthesis of SE 214857, a potent, nonpeptide fibrinogen receptor antagonist, is reported. The synthetic route employs as a key step an intramolecular aryl fluoride displacement to form the seven-membered ring of the 1,4-benzodiazepine system.

引用

页码：9433 / 9436

页数：4

共 12 条

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