Heteroatom transfer to alkenes by N-protected-oxaziridines:: new reaction pathways and products

被引:7
作者
Armstrong, A [1 ]
Edmonds, ID
Swarbrick, ME
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
[2] GlaxoSmithKline, Neurol & Gastrointestinal Dis Ctr Excellence Drug, Harlow CM19 5AW, Essex, England
基金
英国工程与自然科学研究理事会;
关键词
oxaziridines; amination; aziridines; epoxides;
D O I
10.1016/j.tetlet.2005.02.034
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
N-Alkoxycarbonyl- and N-carboxamido-oxaziridines are shown to react with aromatic alkenes to give epoxide, aziridine or hydro-oxidation products, in ratios depending on the oxaziridine structure. Chiral oxaziridines can effect epoxidation and hydro-oxidation with promising levels of asymmetric induction. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2207 / 2210
页数:4
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