Palladium-catalyzed cross-coupling reaction of alkynylzincs with benzylic electrophiles

被引：64

作者：

Qian, MX ^{[1
]}

Negishi, EI ^{[1
]}

机构：

[1] Purdue Univ, Herbert C Brown Lab Chem, W Lafayette, IN 47907 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期

基金：

美国国家卫生研究院;

关键词：

palladium-catalyzed cross-coupling; alkynylzincs; benzylic electrophiles; benzylated alkynes; Pd(DPEphOS)Cl2-;

D O I：

10.1016/j.tetlet.2005.02.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of alkynylzinc bromides with benzyl bromides or chlorides in the presence of a catalytic amount of Pd(DPE-phos)Cl-2 in THF at 23 degrees C cleanly produces the corresponding benzylated alkynes in 73-97% yields. With 10(-3) mol% of Pd(DPE-phos)Cl-2, the maximum turnover number of 7.1 x 10(4) has been observed for the formation of PhC CCH2Ph. (c) 2005 Published by Elsevier Ltd.

引用

页码：2927 / 2930

页数：4

共 20 条

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