Amination of aryl halides using copper catalysis

被引：190

作者：

Lang, FR ^{[1
]}

Zewge, D ^{[1
]}

Houpis, IN ^{[1
]}

Volante, RP ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(01)00458-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bromopyridine 4 was converted into aminopyridine 5 under Cu2O catalysis with an ethylene glycol solution of ammonia in excellent yield (90%). The amination reaction features low (0.5 mol%) catalyst loading, mild reaction temperature (80 degreesC) and low reaction pressure (50 psi). This protocol is further studied in the amination of a variety of aryl halides. (C) 2001 Elsevier Science Ltd. All tights reserved.

引用

页码：3251 / 3254

页数：4

共 22 条

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