Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams

被引：20

作者：

Alcaide, Benito ^{[1
]}

Almendros, Pedro ^{[2
]}

机构：

[1] Univ Complutense Madrid, Fac Quim, Dept Quim Organ 1, Grp Lactamas & Heterociclos Bioactivos,Unidad Aso, E-28040 Madrid, Spain

[2] CSIC, IQOG, E-28006 Madrid, Spain

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 7卷

关键词：

alkynes; allenes; gold; heterocyclizations; beta-lactams; GAMMA-ALLENOLS; REGIOSELECTIVITY CONTROL; ALPHA-HYDROXYALLENES; CARBON-HETEROATOM; BUILDING-BLOCKS; CYCLIZATION; CYCLOISOMERIZATION; HYDROALKOXYLATION; DERIVATIVES; IRON;

D O I：

10.3762/bjoc.7.73

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New gold-catalyzed methods using the beta-lactam scaffold have been recently developed for the synthesis of different sized hetero-cycles. This overview focuses on heterocyclization reactions of allenic and alkynic beta-lactams which rely on the activation of the allene and alkyne component. The mechanism as well as the regio- and stereoselectivity of the cyclizations are also discussed.

引用

页码：622 / 630

页数：9

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