Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea

被引:39
作者
Chang, FR
Wei, JL
Teng, CM
Wu, YC [1 ]
机构
[1] Kaohsiung Med Coll, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
关键词
Annona purpurea; Annonaceae; leaves; antiplatelet aggregation; 7-dehydroaporphine; 7-hydroxy-dehydrothalicsimidine; 7-formyl-dehydrothalicsimidine;
D O I
10.1016/S0031-9422(98)00376-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bioactivity-directed fractionation led to the isolation of two new 7-dehydroaporphine alkaloids, 7-hydroxy-dehydrothalicsimidine (1) and 7-formyl-dehydrothalicsimidine (2), along with the five known alkaloids, thalicsimidine (3), norpurpureine (4), N-methyllaurotetanine (5), lirinidine (6) and N-methylasimilobine (7), from the leaves of Annona purpurea. Structural elucidation of these compounds was established by mass and spectroscopic analyses. Among them, 1, 3, 4, 6 and 7 exhibited significant inhibition of collagen, arachidonic acid and platelet activating factor-induced platelet aggregation; 1 also showed inhibition against thrombin;induced platelet aggregation. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2015 / 2018
页数:4
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