Antibody-catalyzed activation of a model tripartate prodrug by a tandem hydrolysis-1,6-elimination reaction

被引：8

作者：

Dinaut, AN ^{[1
]}

Taylor, SD ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 15期

关键词：

D O I：

10.1039/b103971g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Activation of a model tripartate prodrug was achieved by abzyme-catalyzed hydrolysis of an N-methylcarbamate moiety followed by a spontaneous 1,6-elimination reaction.

引用

页码：1386 / 1387

页数：2

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