Hydrolysis of an N-methylcarbamate by a catalytic antibody

被引：9

作者：

Dinaut, AN

Chen, MJ

Marks, A

Batey, RA

Taylor, SD

机构：

[1] Univ Toronto, Dept Chem, Mississauga, ON L5L 1C6, Canada

[2] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

[3] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 05期

关键词：

D O I：

10.1039/b000468p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of antibody-catalyzed hydrolysis of an N-methylcarbamate, a highly challenging reaction for antibody catalysis, was achieved by raising a monoclonal antibody to a phosphoramidate transition state analogue.

引用

页码：385 / 386

页数：2

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