Modus operandi of the bacterial RNA polymerase containing the σ54 promoter-specificity factor

被引：96

作者：

Wigneshweraraj, Sivaramesh ^{[1
]}

Bose, Daniel ^{[2
]}

Burrows, Patricia C. ^{[3
]}

Joly, Nicolas ^{[3
]}

Schumacher, Joerg ^{[3
]}

Rappas, Mathieu ^{[4
]}

Pape, Tillmann ^{[2
]}

Zhang, Xiaodong ^{[2
]}

Stockley, Peter ^{[5
]}

Severinov, Konstantin ^{[6
,7
,8
]}

Buck, Martin

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Invest Sci, Dept Microbiol, Fac Med, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, Dept Life Sci, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Div Biol, Dept Life Sci, London SW7 2AZ, England

[4] Inst Canc Res, Chester Beatty Labs, Sect Struct Biol, London SW3 6JB, England

[5] Univ Leeds, Astburt Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[6] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

[7] Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ 08854 USA

[8] Russian Acad Sci, Inst Genet Biol, Moscow 123182, Russia

来源：

MOLECULAR MICROBIOLOGY | 2008年 / 68卷 / 03期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1111/j.1365-2958.2008.06181.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial sigma (sigma) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative sigma factor sigma(54) confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the sigma(54) factor makes with the bacterial transcription machinery.

引用

页码：538 / 546

页数：9

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