Interactions of Neisseria gonorrhoeae with mature human macrophage opacity proteins influence production of proinflammatory cytokines

被引：24

作者：

Makepeace, BL ^{[1
]}

Watt, PJ ^{[1
]}

Heckels, JE ^{[1
]}

Christodoulides, M ^{[1
]}

机构：

[1] Univ Southampton, Sch Med, Mol Microbiol Grp, Div Cell & Mol Med,Southampton Gen Hosp, Southampton SO16 6YD, Hants, England

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.69.3.1909-1913.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathological features of ascending gonococcal infection suggest that proinflammatory mediators secreted by tissue-resident macrophages are important components of the host response. Challenge of fully differentiated, mature macrophages with variants of Neisseria gonorrhoeae strain P9 or purified bacterial surface components (pili, lipooligosaccharide, and outer membrane vesicles) induced the secretion of interleukin 6 (IL-6), tumor necrosis factor alpha, growth-related protein alpha, macrophage inflammatory protein 1 alpha (MTP-1 alpha), and RANTES cytokines but had no effect on IL-8 production. No secretion of IL-1 beta, epithelial-derived neutrophil attractant 78, granulocyte-macrophage colony-stimulating factor, IL-10, or IL-12 cytokines was observed. Notably, the P9-Opa(b) protein, in comparison to P9-Opa(a,) increased the association of gonococci with macrophages and elevated the secretion of cytokines. Thus, variation in Opa protein expression by the gonococcus may be a determining factor in the severity of pelvic inflammatory disease.

引用

页码：1909 / 1913

页数：5

共 32 条

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