Imaging brain connectivity in children with diverse reading ability

被引：217

作者：

Beaulieu, C ^{[1
]}

Plewes, C ^{[1
]}

Paulson, LA ^{[1
]}

Roy, D ^{[1
]}

Snook, L ^{[1
]}

Concha, L ^{[1
]}

Phillips, L ^{[1
]}

机构：

[1] Univ Alberta, Fac Med & Dent, Dept Biomed Engn, Res Transit Facil 1098, Edmonton, AB T6G 2V2, Canada

来源：

NEUROIMAGE | 2005年 / 25卷 / 04期

基金：

加拿大健康研究院;

关键词：

dyslexia; magnetic resonance imaging; MRI; reading; diffusion tensor imaging; DTI; brain;

D O I：

10.1016/j.neuroimage.2004.12.053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reading is a complex cognitive skill that requires the coordination of multiple brain regions. Although functional neuroimaging studies highlight the cortical brain regions associated with a specific cognitive task like reading, they do not directly address the underlying neural connections necessary for efficient performance of this task. Adults with reading disability have demonstrated lower regional white matter connectivity, but it is not known whether this relationship between neuronal wiring and reading performance also holds in younger readers. Using diffusion tensor magnetic resonance imaging (DTI) that highlights the structural integrity of the brain wiring, we show that regional brain connectivity in the left temporo-parietal white matter correlates with a wide range of reading ability in children as young as 8-12 years old. Diffusion tensor tractography suggests that the posterior limb of the internal capsule is consistent with the location of the largest cluster of correlation between reading ability (Word Identification subtest) and fractional anisotropy. The maturation of the white matter may play a key role in the development of cognitive processes such as reading. © 2005 Elsevier Inc. All rights reserved.

引用

页码：1266 / 1271

页数：6

共 32 条

[31] Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI [J].