Fatal disseminated Trichoderma longibrachiatum infection in an adult bone marrow transplant patient:: Species identification and review of the literature

被引:58
作者
Richter, S
Cormican, MG
Pfaller, MA
Lee, CK
Gingrich, R
Rinaldi, MG
Sutton, DA
机构
[1] Univ Iowa, Coll Med, Dept Pathol, Div Med Microbiol, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Med, Iowa City, IA 52242 USA
[3] Univ Texas, Hlth Sci Ctr, Dept Pathol, Fungus Testing Lab, San Antonio, TX 78284 USA
[4] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX 78284 USA
关键词
D O I
10.1128/JCM.37.4.1154-1160.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Trichoderma longibrachiatum was recovered from stool surveillance cultures and a perirectal ulcer biopsy specimen from a 29-year-old male who had received an allogeneic bone marrow transplant for acute lymphoblastic leukemia. The amphotericin B (2.0 mu g/ml) and itraconazole (1.0 mu g/ml) MICs for the organism were elevated. Therapy with these agents was unsuccessful, and the patient died on day 58 posttransplantation, At autopsy, histologic sections from the lungs, liver, brain, and intestinal wall showed infiltration by branching septate hyphae, Cultures were positive for Trichoderma longibrachiatum. While Trichoderma species have been recognized to be pathogenic in profoundly immunosuppressed hosts with increasing frequency, this is the first report of probable acquisition through the gastrointestinal tract. Salient features regarding the identification of molds in the Trichoderma longibrachiatum species aggregate are presented.
引用
收藏
页码:1154 / 1160
页数:7
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