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Multilevel, Dynamic Chronic Obstructive Pulmonary Disease Heterogeneity A Challenge for Personalized Medicine

被引：21
作者：
Faner, Rosa [1 ,2 ]
Agusti, Alvar [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Ctr Invest Biomed Red Resp Dis CIBERES, Madrid, Spain
[2] Fundacio Clin Recerca Biomed, Barcelona, Spain
[3] Hosp Clin Barcelona, Inst Resp, Barcelona, Spain
[4] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
[5] Univ Barcelona, Barcelona, Spain
来源：
ANNALS OF THE AMERICAN THORACIC SOCIETY | 2016年 / 13卷
关键词：
emphysema; bronchitis; network analysis; biomarkers; lung function; CELL LUNG-CANCER; PRECISION MEDICINE; COPD; NETWORK; COMORBIDITIES; SIGNATURE;
D O I：
10.1513/AnnalsATS.201605-372AW
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
This article summarizes how the multilevel (clinical, functional, structural, and biological) and dynamic (i.e., subjected to changes with time) heterogeneity of chronic obstructive pulmonary disease challenges a personalized approach for these patients. In particular, the following issues are discussed: (1) the conceptual differences between personalized and precision medicine, (2) how to frame the complexity and heterogeneity of chronic obstructive pulmonary disease by considering the precise meaning of the terms personalized medicine and precision medicine, and (3) how to translate all these novel concepts into clinical practice and move the field forward.
引用
收藏
页码：S466 / S470
页数：5
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共 26 条
  • [1] Treatable traits: toward precision medicine of chronic airway diseases
    Agusti, Alvar
    Bel, Elisabeth
    Thomas, Mike
    Vogelmeier, Claus
    Brusselle, Guy
    Holgate, Stephen
    Humbert, Marc
    Jones, Paul
    Gibson, Peter G.
    Vestbo, Jorgen
    Beasley, Richard
    Pavord, Ian D.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) : 410 - 419
  • [2] Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issues Summary of a BRN-AJRCCM Workshop Held in Barcelona on June 12, 2014
    Agusti, Alvar
    Anto, Josep Maria
    Auffray, Charles
    Barbe, Ferran
    Barreiro, Esther
    Dorca, Jordi
    Escarrabill, Joan
    Faner, Rosa
    Furlong, Laura I.
    Garcia-Aymerich, Judith
    Gea, Joaquim
    Lindmark, Bertil
    Monso, Eduard
    Plaza, Vicente
    Puhan, Milo A.
    Roca, Josep
    Ruiz-Manzano, Juan
    Sampietro-Colom, Laura
    Sanz, Ferran
    Serrano, Luis
    Sharpe, James
    Sibila, Oriol
    Silverman, Edwin K.
    Sterk, Peter J.
    Sznajder, Jacob I.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191 (04) : 391 - 401
  • [3] The path to personalised medicine in COPD
    Agusti, Alvar
    [J]. THORAX, 2014, 69 (09) : 857 - 864
  • [4] The COPD control panel: towards personalised medicine in COPD
    Agusti, Alvar
    MacNee, William
    [J]. THORAX, 2013, 68 (07) : 687 - 690
  • [5] Current Controversies and Future Perspectives in Chronic Obstructive Pulmonary Disease
    Agusti, Alvar
    Vestbo, Jorgen
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 184 (05) : 507 - 513
  • [6] Characterisation of COPD heterogeneity in the ECLIPSE cohort
    Agusti, Alvar
    Calverley, Peter M. A.
    Celli, Bartolome
    Coxson, Harvey O.
    Edwards, Lisa D.
    Lomas, David A.
    MacNee, William
    Miller, Bruce E.
    Rennard, Steve
    Silverman, Edwin K.
    Tal-Singer, Ruth
    Wouters, Emiel
    Yates, Julie C.
    Vestbo, Jorgen
    [J]. RESPIRATORY RESEARCH, 2010, 11
  • [7] The Role of CT Scanning in Multidimensional Phenotyping of COPD
    Bafadhel, Mona
    Umar, Imran
    Gupta, Sumit
    Raj, J. Vimal
    Vara, Dhiraj D.
    Entwisle, James J.
    Pavord, Ian D.
    Brightling, Christopher E.
    Siddiqui, Salman
    [J]. CHEST, 2011, 140 (03) : 634 - 642
  • [8] The Angelina effect: immediate reach, grasp, and impact of going public
    Borzekowski, Dina L. G.
    Guan, Yue
    Smith, Katherine C.
    Erby, Lori H.
    Roter, Debra L.
    [J]. GENETICS IN MEDICINE, 2014, 16 (07) : 516 - 521
  • [9] COPD comorbidities network
    Divo, Miguel J.
    Casanova, Ciro
    Marin, Jose M.
    Pinto-Plata, Victor M.
    de-Torres, Juan P.
    Zulueta, Javier J.
    Cabrera, Carlos
    Zagaceta, Jorge
    Sanchez-Salcedo, Pablo
    Berto, Juan
    Baz Davila, Rebeca
    Alcaide, Ana B.
    Cote, Claudia
    Celli, Bartolome R.
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2015, 46 (03) : 640 - 650
  • [10] Factors associated with change in exacerbation frequency in COPD
    Donaldson, Gavin C.
    Muellerova, Hanna
    Locantore, Nicholas
    Hurst, John R.
    Calverley, Peter M. A.
    Vestbo, Jorgen
    Anzueto, Antonio
    Wedzicha, Jadwiga A.
    [J]. RESPIRATORY RESEARCH, 2013, 14
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