Widespread genetic incompatibility in C. elegans maintained by balancing selection

被引:203
作者
Seidel, Hannah S. [1 ]
Rockman, Matthew V.
Kruglyak, Leonid
机构
[1] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA
关键词
D O I
10.1126/science.1151107
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel- 1 arrest if their sperm parent carries an incompatible allele of a second, paternal- effect locus, peel- 1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long- term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.
引用
收藏
页码:589 / 594
页数:6
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