The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma

被引：45

作者：

Guo, X. ^{[1
,2
]}

Shi, M. ^{[2
]}

Sun, L. ^{[2
]}

Wang, Y. ^{[2
]}

Gui, Y. ^{[2
]}

Cai, Z. ^{[2
]}

Duan, X. ^{[1
]}

机构：

[1] Hebei Normal Univ, Coll Life Sci, Lab Mol Iron Metab, Shijiazhuang 050016, Hebei, Peoples R China

[2] Peking Univ, Shenzhen Hosp, Guangdong Key Lab Male Reprod Med & Genet, Shenzhen 518036, Peoples R China

来源：

NEOPLASMA | 2011年 / 58卷 / 02期

基金：

中国国家自然科学基金;

关键词：

renal cell carcinoma; histone demethylase; JMJD1A; hypoxia-inducible factor; iron; HYPOXIA-INDUCIBLE FACTORS; CANCER; NICKEL; PROLIFERATION; DERNETHYLASE; ASCORBATE; DEPLETION; TARGETS; HIF;

D O I：

10.4149/neo_2011_02_153

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Hypoxia-inducible factor la has been shown to play a central role in RCC tumorigenesis by acting as a transcription factor. Histone demethylase JMJD1A is an iron- and 2-oxoglutarate-dependent dioxygenase which catalyze the demethylation of mono- and dimethylated H3K9. JMJD1A can be upregulated by hypoxia via HIF-1 and associated with cancer. The expression of JMJD1A was determined in 10 kidney cancer tissue and adjacent tissue by quantitative polymerase chain reaction, western blotting and immunohistochemistry. Furthermore, the expression of JMJD1A was investigated in cell line 786-0 through adding nickle or cobalt ion to mimic hypoxic environment. The expression of JMJD1A was higher in cancer tissue than adjacent tissue, and in hypoxic environment than normal environment. In cancer tissue, the JMJD1A mainly located around blood vessels which indicated that JMJD1A is involved tumor angiogenesis. Conclusion: the increased expression of JMJD1A might be associated with the progression of kidney cancer.

引用

页码：153 / 157

页数：5

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