Left inferior parietal cortex integrates time and space during collision judgments

被引:91
作者
Assmus, A
Marshall, JC
Ritzl, A
Noth, J
Zilles, K
Fink, GR
机构
[1] Forschungszentrum Julich, Inst Med, D-52425 Julich, Germany
[2] Rhein Westfal TH Aachen, Dept Neurol, D-5100 Aachen, Germany
[3] Univ Oxford, Dept Clin Neurol, Oxford, England
[4] Univ Hertfordshire, Dept Psychol, Hatfield, Herts, England
[5] C&O Vogt Brain Res Inst, Dusseldorf, Germany
关键词
D O I
10.1016/j.neuroimage.2003.09.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Left inferior parietal lobe lesions can cause perturbation of the space-time plans underlying skilled actions. But does the perceptual integration of spatiotemporal information use the same neural substrate or is the role of the left inferior parietal cortex restricted to visuomotor transformations? We use fMRI and a collision judgment paradigm to examine whether the left inferior parietal cortex integrates temporal and spatial variables in situations in which no complex action and no visuomotor transformation is required. We used a perceptual task in which healthy subjects indicated by simple button presses whether two moving objects (of the same or different size) would or would not collide with each other. This task of interest was contrasted with a control task that employed the same stimuli and identical motor responses but in which the size of the two moving objects had to be compared. To assess putative differential eye-movement effects both tasks were performed with and without central fixation. Analysis of the fMRI data (employing a random-effects model and SPM99) showed that collision judgments (relative to size judgments) provoked a significant increase in neural activity in the left inferior parietal cortex (supramarginal gyrus) only. These results show that left inferior parietal cortex is involved in the integration of perceptual spatiotemporal information and thus provide a neural correlate for the use of space-time plans (whose perturbation can lead to apraxia as originally hypothesized by Liepmann). Furthermore, the data suggest that the left supramarginal gyrus combines temporal and spatial variables more widely than previously supposed. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:S82 / S88
页数:7
相关论文
共 29 条
[1]   Cognitive representations of hand posture in ideomotor apraxia [J].
Buxbaum, LJ ;
Sirigu, A ;
Schwartz, MF ;
Klatzky, R .
NEUROPSYCHOLOGIA, 2003, 41 (08) :1091-1113
[2]  
CORBETTA M, 1991, J NEUROSCI, V11, P2383
[3]  
Coull JT, 1998, J NEUROSCI, V18, P7426
[4]   Cortical fMRI activation produced by attentive tracking of moving targets [J].
Culham, JC ;
Brandt, SA ;
Cavanagh, P ;
Kanwisher, NG ;
Dale, AM ;
Tootell, RBH .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (05) :2657-2670
[5]  
De Renzi E., 1999, HDB CLIN EXPT NEUROP
[6]   YOUNG CHILDRENS LEARNING ON ROAD-CROSSING SIMULATIONS [J].
DEMETRE, JD ;
LEE, DN ;
GRIEVE, R ;
PITCAIRN, TK ;
AMPOFOBOATENG, K ;
THOMSON, JA .
BRITISH JOURNAL OF EDUCATIONAL PSYCHOLOGY, 1993, 63 :349-359
[7]   Space-based and object-based visual attention: shared and specific neural domains [J].
Fink, GR ;
Dolan, RJ ;
Halligan, PW ;
Marshall, JC ;
Frith, CD .
BRAIN, 1997, 120 :2013-2028
[8]   ANALYSIS OF FMRI TIME-SERIES REVISITED [J].
FRISTON, KJ ;
HOLMES, AP ;
POLINE, JB ;
GRASBY, PJ ;
WILLIAMS, SCR ;
FRACKOWIAK, RSJ ;
TURNER, R .
NEUROIMAGE, 1995, 2 (01) :45-53
[9]  
GITELMAN DR, 2001, ILAB PROGRAM ANAL EY
[10]   Neural representations of skilled movement [J].
Haaland, KY ;
Harrington, DL ;
Knight, RT .
BRAIN, 2000, 123 :2306-2313