Mechanisms of apoptosis in the heart

被引：140

作者：

Gustafsson, ÅB ^{[1
]}

Gottlieb, RA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol & Expt Med, MEM 220, La Jolla, CA 92037 USA

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 2003年 / 23卷 / 06期

关键词：

apoptosis; cardiac myocytes; mitochondria; death receptors; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; FAS-MEDIATED APOPTOSIS; MITOCHONDRIAL PERMEABILITY TRANSITION; SIGNAL-TRANSDUCTION PATHWAYS; CASPASE RECRUITMENT DOMAIN; CULTURED CARDIAC MYOCYTES; HYPOXIA INDUCES APOPTOSIS; RAT VENTRICULAR MYOCYTES;

D O I：

10.1023/B:JOCI.0000010421.56035.60

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis is a complex and highly regulated form of cell death, and believed to contribute to the continuous decline of ventricular function in heart failure. Apoptotic cell death is observed in a variety of cardiovascular diseases, including myocardial infarction, ischemia-reperfusion injury, end-stage heart failure, arrhythmias, and adriamycin cardiomyopathy. There are several pathways leading to programmed cell death. Apoptosis can be initiated by extracellular or intracellular stimuli, leading to the activation of caspases and subsequent cell death. A better understanding of the process of apoptosis in the heart is clearly important as it may lead to the identification of novel therapies for cardiovascular disease. This review is focused on the basic cellular mechanisms of apoptosis, as well as our current understanding of this process in the heart.

引用

页码：447 / 459

页数：13

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