Positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (mGluR2)

被引：25

作者：

Rudd, MT ^{[1
]}

McCauley, JA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Med Chem, West Point, PA 19486 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 09期

关键词：

glutamate; mGluR2; mGluR3; group II; potentiator; agonist;

D O I：

10.2174/1568026054750281

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This article describes recent medicinal chemistry progress toward selective potentiators of the metabotropic glutamate receptor 2 (mGluR2). Groups at Lilly and Merck have identified new classes of potentiators that exhibit selectivity for mGluR2 over the seven other subtypes of mGluRs. Structure-activity relationships as well as pharmacokinetic properties and in vivo activity are reviewed.

引用

页码：869 / 884

页数：16

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