The glamour and gloom of glycogen synthase kinase-3

被引：1314

作者：

Jope, RS ^{[1
]}

Johnson, GVW ^{[1
]}

机构：

[1] Univ Alabama, Dept Psychiat & Behav Neurobiol, Sparks Ctr 1057, Birmingham, AL 35294 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2004年 / 29卷 / 02期

关键词：

D O I：

10.1016/j.tibs.2003.12.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly large number of cellular processes and diseases. Several mechanisms play a part in controlling the actions of GSK3, including phosphorylation, protein complex formation, and subcellular distribution. These are used to control and direct the far-reaching influences of GSK3 on cellular structure, growth, motility and apoptosis. Dysregulation of GSK3 is linked to several prevalent pathological conditions, such as diabetes and/or insulin resistance, and Alzheimer's disease. Therefore, much effort is currently directed towards understanding the functions and control of GSK3, and identifying methods capable of diminishing the deleterious impact of GSK3 in pathological conditions.

引用

页码：95 / 102

页数：8

共 71 条

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