Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes

被引：129

作者：

Yang, Sheng-Tao ^{[1
,2
]}

Luo, Jianbin ^{[2
]}

Zhou, Qinghan ^{[2
]}

Wang, Haifang ^{[1
]}

机构：

[1] Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China

[2] SW Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Peoples R China

来源：

THERANOSTICS | 2012年 / 2卷 / 03期

关键词：

Carbon nanotubes; pharmacokinetics; metabolism; toxicity; biomedical applications; IN-VIVO; RAMAN-SPECTROSCOPY; DRUG-DELIVERY; MICE; BIODISTRIBUTION; CANCER; FUNCTIONALIZATION; TRANSLOCATION; ACCUMULATION; CIRCULATION;

D O I：

10.7150/thno.3618

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Carbon nanotubes (CNTs) have attracted great interest of the nano community and beyond. However, the biomedical applications of CNTs arouse serious concerns for their unknown in vivo consequence, in which the information of pharmacokinetics, metabolism and toxicity of CNTs is essential. In this review, we summarize the updated data of CNTs from the biomedical view. The information shows that surface chemistry is crucial in regulating the in vivo behaviors of CNTs. Among the functionalization methods, PEGylation is the most efficient one to improve the pharmacokinetics and biocompatibility of CNTs. The guiding effects of the pharmacokinetics, metabolism and toxicity information on the biomedical applications of CNTs are discussed.

引用

页码：271 / 282

页数：12

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