Carbon nanotubes as photoacoustic molecular imaging agents in living mice

被引：947

作者：

De La Zerda, Adam ^{[1
,2
,3
]}

Zavaleta, Cristina ^{[1
,2
]}

Keren, Shay ^{[1
,2
]}

Vaithilingam, Srikant ^{[3
]}

Bodapati, Sunil ^{[1
,2
]}

Liu, Zhuang ^{[4
]}

Levi, Jelena ^{[1
,2
]}

Smith, Bryan R. ^{[1
,2
]}

Ma, Te-Jen ^{[3
]}

Oralkan, Omer ^{[3
]}

Cheng, Zhen ^{[1
,2
]}

Chen, Xiaoyuan ^{[1
,2
]}

Dai, Hongjie ^{[4
]}

Khuri-Yakub, Butrus T. ^{[3
]}

Gambhir, Sanjiv S. ^{[1
,2
,5
]}

机构：

[1] Stanford Univ, Mol Imaging Program Stanford, Dept Radiol, Palo Alto, CA 94305 USA

[2] Stanford Univ, BioX Program, Palo Alto, CA 94305 USA

[3] Stanford Univ, Dept Elect Engn, Palo Alto, CA 94305 USA

[4] Stanford Univ, Dept Chem, Palo Alto, CA 94305 USA

[5] Stanford Univ, Dept Bioengn, Palo Alto, CA 94305 USA

来源：

NATURE NANOTECHNOLOGY | 2008年 / 3卷 / 09期

关键词：

D O I：

10.1038/nnano.2008.231

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Photoacoustic imaging of living subjects offers higher spatial resolution and allows deeper tissues to be imaged compared with most optical imaging techniques(1-7). As many diseases do not exhibit a natural photoacoustic contrast, especially in their early stages, it is necessary to administer a photoacoustic contrast agent. A number of contrast agents for photoacoustic imaging have been suggested previously(8-15), but most were not shown to target a diseased site in living subjects. Here we show that single-walled carbon nanotubes conjugated with cyclic Arg-Gly-Asp (RGD) peptides can be used as a contrast agent for photoacoustic imaging of tumours. Intravenous administration of these targeted nanotubes to mice bearing tumours showed eight times greater photoacoustic signal in the tumour than mice injected with non-targeted nanotubes. These results were verified ex vivo using Raman microscopy. Photoacoustic imaging of targeted single-walled carbon nanotubes may contribute to non-invasive cancer imaging and monitoring of nanotherapeutics in living subjects(16).

引用

页码：557 / 562

页数：6

共 27 条

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American National Standards Institute, 2000, AM NAT STAND CENTR P

[2] Applications of carbon nanotubes in drug delivery [J].