Targeting PI3K/mTOR Signaling in Cancer

被引：33

作者：

Emerling, Brooke M. ^{[2
,3
]}

Akcakanat, Argun ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[2] Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USA

来源：

CANCER RESEARCH | 2011年 / 71卷 / 24期

关键词：

RAG GTPASES; RAPAMYCIN; INHIBITOR; MTORC1; ACTIVATION; EXPRESSION; GROWTH; GLIOMA;

D O I：

10.1158/0008-5472.CAN-11-1699

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The American Association for Cancer Research (AACR) Special Conference on Targeting PI3K/mTOR Signaling in Cancer was held in San Francisco, California from February 24 to 27, 2011. The meeting was cochaired by Drs. Lewis C. Cantley, David M. Sabatini, and Funda Meric-Bernstam. The main focus of this event was the therapeutic potential of drugs targeting the PI3K/mTOR signaling pathway for the treatment of cancer. This article summarizes the recent discoveries in the field, with particular emphasis on the major themes of the conference. Cancer Res; 71(24); 7351-9. (C) 2011 AACR.

引用

页码：7351 / 7359

页数：9

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