Pathogenicity islands in bacterial pathogenesis

被引:467
作者
Schmidt, H
Hensel, M
机构
[1] Tech Univ Dresden, Inst Med Mikrobiol & Hyg, Med Fak Carl Gustav Carus, D-01307 Dresden, Germany
[2] Univ Erlangen Nurnberg, Inst Klin Mikrobiol Immunol & Hyg, Erlangen, Germany
关键词
D O I
10.1128/CMR.17.1.14-56.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In this review, we focus on a group of mobile genetic elements designated pathogenicity islands (PAI). These elements play a pivotal role in the virulence of bacterial pathogens of humans and are also essential for virulence in pathogens of animals and plants. Characteristic molecular features of PAI of important human pathogens and their role in pathogenesis are described. The availability of a large number of genome sequences of pathogenic bacteria and their benign relatives currently offers a unique opportunity for the identification of novel pathogen-specific genomic islands. However, this knowledge has to be complemented by improved model systems for the analysis of virulence functions of bacterial pathogens. PAI apparently have been acquired during the speciation of pathogens from their nonpathogenic or environmental ancestors. The acquisition of PAI not only is an ancient evolutionary event that led to the appearance of bacterial pathogens on a timescale of millions of years but also may represent a mechanism that contributes to the appearance of new pathogens within a human life span. The acquisition of knowledge about PAI, their structure, their mobility, and the pathogenicity factors they encode not only is helpful in gaining a better understanding of bacterial evolution and interactions of pathogens with eukaryotic host cells but also may have important practical implications such as providing delivery systems for vaccination, tools for cell biology, and tools for the development of new strategies for therapy of bacterial infections.
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页码:14 / +
页数:45
相关论文
共 386 条
[1]   Analyses of the cag pathogenicity island of Helicobacter pylori [J].
Akopyants, NS ;
Clifton, SW ;
Kersulyte, D ;
Crabtree, JE ;
Youree, BE ;
Reece, CA ;
Bukanov, NO ;
Drazek, ES ;
Roe, BA ;
Berg, DE .
MOLECULAR MICROBIOLOGY, 1998, 28 (01) :37-53
[2]   The sigA gene which is borne on the she pathogenicity island of Shigella flexneri 2a encodes an exported cytopathic protease involved in intestinal fluid accumulation [J].
Al-Hasani, K ;
Henderson, IR ;
Sakellaris, H ;
Rajakumar, K ;
Grant, T ;
Nataro, JP ;
Robins-Browne, R ;
Adler, B .
INFECTION AND IMMUNITY, 2000, 68 (05) :2457-2463
[3]   The Pseudomonas syringae Hrp pathogenicity island has a tripartite mosaic structure composed of a cluster of type III secretion genes bounded by exchangeable effector and conserved effector loci that contribute to parasitic fitness and pathogenicity in plants [J].
Alfano, JR ;
Charkowski, AO ;
Deng, WL ;
Badel, JL ;
Petnicki-Ocwieja, T ;
van Dijk, K ;
Collmer, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4856-4861
[4]   The type III (Hrp) secretion pathway of plant pathogenic bacteria: trafficking harpins, Avr proteins, and death [J].
Alfano, JR ;
Collmer, A .
JOURNAL OF BACTERIOLOGY, 1997, 179 (18) :5655-5662
[5]   Serotype-converting bacteriophages and O-antigen modification in Shigella flexneri [J].
Allison, GE ;
Verma, NK .
TRENDS IN MICROBIOLOGY, 2000, 8 (01) :17-23
[6]   What can we learn with wavelets about DNA sequences? [J].
Arneodo, A ;
D'Aubenton-Carafa, Y ;
Audit, B ;
Bacry, E ;
Muzy, JF ;
Thermes, C .
PHYSICA A, 1998, 249 (1-4) :439-448
[7]   A genomic island in Pseudomonas aeruginosa carries the determinants of flagellin glycosylation [J].
Arora, SK ;
Bangera, M ;
Lory, S ;
Ramphal, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (16) :9342-9347
[8]   Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells [J].
Asahi, M ;
Azuma, T ;
Ito, S ;
Ito, Y ;
Suto, H ;
Nagai, Y ;
Tsubokawa, M ;
Tohyama, Y ;
Maeda, S ;
Omata, M ;
Suzuki, T ;
Sasakawa, C .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :593-602
[9]   Genome and virulence determinants of high virulence community-acquired MRSA [J].
Baba, T ;
Takeuchi, F ;
Kuroda, M ;
Yuzawa, H ;
Aoki, K ;
Oguchi, A ;
Nagai, Y ;
Iwama, N ;
Asano, K ;
Naimi, T ;
Kuroda, H ;
Cui, L ;
Yamamoto, K ;
Hiramatsu, K .
LANCET, 2002, 359 (9320) :1819-1827
[10]   Staphylococcus aureus enterotoxins:: a key in airway disease? [J].
Bachert, C ;
Gevaert, P ;
van Cauwenberge, P .
ALLERGY, 2002, 57 (06) :480-487