Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

被引：456

作者：

Jensen, Soren ^{[1
]}

Thomsen, Allan Randrup ^{[1
]}

机构：

[1] Univ Copenhagen, Inst Int Hlth Immunol & Microbiol, Copenhagen, Denmark

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 06期

关键词：

TOLL-LIKE RECEPTOR; DOUBLE-STRANDED-RNA; PLASMACYTOID DENDRITIC CELLS; NF-KAPPA-B; WEST-NILE-VIRUS; LYMPHOCYTIC-CHORIOMENINGITIS-VIRUS; PATTERN-RECOGNITION RECEPTORS; INTERFERON ANTIVIRAL RESPONSE; RESPIRATORY SYNCYTIAL VIRUS; IRF3 TRANSCRIPTION FACTOR;

D O I：

10.1128/JVI.05738-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

引用

页码：2900 / 2910

页数：11

共 143 条

[51] Inflammasome recognition of influenza virus is essential for adaptive immune responses [J].

Ichinohe, Takeshi ;

Lee, Heung Kyu ;

Ogura, Yasunori ;

Flavell, Richard ;

Iwasaki, Akiko .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (01) :79-87

[52] STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling [J].

Ishikawa, Hiroki ;

Barber, Glen N. .

NATURE, 2008, 455 (7213) :674-U74

[53] Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7 [J].

Jia, Yongxia ;

Song, Ting ;

Wei, Congwen ;

Ni, Caifei ;

Zheng, Zirui ;

Xu, Quanbin ;

Ma, Hongfang ;

Li, Li ;

Zhang, Yanhong ;

He, Xiang ;

Xu, Yang ;

Shi, Wei ;

Zhong, Hui .

JOURNAL OF IMMUNOLOGY, 2009, 183 (07) :4241-4248

[54] Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848 [J].

Jurk, M ;

Heil, F ;

Vollmer, J ;

Schetter, C ;

Krieg, AM ;

Wagner, H ;

Lipford, G ;

Bauer, S .

NATURE IMMUNOLOGY, 2002, 3 (06) :499-499

[55] Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry [J].

Kane, Melissa ;

Case, Laure K. ;

Wang, Christine ;

Yurkovetskiy, Leonid ;

Dikiy, Stanislav ;

Golovkina, Tatyana V. .

IMMUNITY, 2011, 35 (01) :135-145

[56] Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5:: a novel type I interferon-responsive apoptosis-inducing gene [J].

Kang, DC ;

Gopalkrishnan, RV ;

Lin, L ;

Randolph, A ;

Valerie, K ;

Pestka, S ;

Fisher, PB .

ONCOGENE, 2004, 23 (09) :1789-1800

[57] mda-5:: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties [J].

Kang, DC ;

Gopalkrishnan, RV ;

Wu, QP ;

Jankowsky, E ;

Pyle, AM ;

Fisher, PB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :637-642

[58] Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA [J].

Kanneganti, Thirumala-Devi ;

Body-Malapel, Mathilde ;

Amer, Amal ;

Park, Jong-Hwan ;

Whitfield, Joel ;

Franchi, Luigi ;

Taraporewala, Zenobia F. ;

Miller, David ;

Patton, John T. ;

Inohara, Naohiro ;

Nunez, Gabriel .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (48) :36560-36568

[59] Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses [J].

Kato, H ;

Takeuchi, O ;

Sato, S ;

Yoneyama, M ;

Yamamoto, M ;

Matsui, K ;

Uematsu, S ;

Jung, A ;

Kawai, T ;

Ishii, KJ ;

Yamaguchi, O ;

Otsu, K ;

Tsujimura, T ;

Koh, CS ;

Sousa, CRE ;

Matsuura, Y ;

Fujita, T ;

Akira, S .

NATURE, 2006, 441 (7089) :101-105

[60] Cell type-specific involvement of RIG-I in antiviral response [J].