Quantitative multiresidue method for about 100 veterinary drugs in different meat matrices by sub 2-μm particulate high-performance liquid chromatography coupled to time of flight mass spectrometry

被引：198

作者：

Kaufmann, Anton ^{[1
]}

Butcher, Patrick ^{[1
]}

Maden, Kathryn ^{[1
]}

Widmer, Mirjam ^{[1
]}

机构：

[1] Kantonales Labor Zurich, Official Food Control Author Canton Zurich, CH-8030 Zurich, Switzerland

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1194卷 / 01期

关键词：

veterinary drugs; multiresidue; TOF; UPLC; extraction;

D O I：

10.1016/j.chroma.2008.03.089

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A quantitative multiresidue method covering more than 100 veterinary drugs, belonging to different drug families, has been developed. The proposed approach uses an liquid-liquid-solid extraction technique (bipolarity extraction) which is capable in recovering polar, medium polar and apolar compounds. A thorough generic reversed phase solid-phase extraction (SPE) clean-up removes interfering proteins and provides clean and stable extracts. Dedicated rinsing steps are proposed to reduce analyte adsorption on glass walls and on precipitating proteins. The resulting extract is analyzed by ultra-performance liquid chromatography (UPLC) coupled to time of flight mass spectrometry (TOF). The method was validated according to the Commission Decision 2002/657/EEC. Validation coved the relevant meat matrices (muscle, kidney and liver). (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：66 / 79

页数：14

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