In the right place at the right time: visualizing and understanding mRNA localization

被引：432

作者：

Buxbaum, Adina R. ^{[1
,2
]}

Haimovich, Gal ^{[1
,2
]}

Singer, Robert H. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10461 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2015年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

YEAST SACCHAROMYCES-CEREVISIAE; GREEN FLUORESCENT PROTEIN; IN-VITRO RECONSTITUTION; ZIPCODE-BINDING PROTEIN; ACTIN GENE-EXPRESSION; XENOPUS-OOCYTES; HIPPOCAMPAL-NEURONS; ENDOPLASMIC-RETICULUM; DENDRITIC TRANSPORT; PARTICLE TRACKING;

D O I：

10.1038/nrm3918

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The spatial regulation of protein translation is an efficient way to create functional and structural asymmetries in cells. Recent research has furthered our understanding of how individual cells spatially organize protein synthesis, by applying innovative technology to characterize the relationship between mRNAs and their regulatory proteins, single-mRNA trafficking dynamics, physiological effects of abrogating mRNA localization in vivo and for endogenous mRNA labelling. The implementation of new imaging technologies has yielded valuable information on mRNA localization, for example, by observing single molecules in tissues. The emerging movements and localization patterns of mRNAs in morphologically distinct unicellular organisms and in neurons have illuminated shared and specialized mechanisms of mRNA localization, and this information is complemented by transgenic and biochemical techniques that reveal the biological consequences of mRNA mislocalization.

引用

页码：95 / 109

页数：15

共 176 条

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