Glutathione S-Transferases and prevention of cellular free radical damage

被引：124

作者：

Ketterer, B ^{[1
]}

机构：

[1] UCL, Sch Med, Dept Oncol, London W1P 8BT, England

来源：

FREE RADICAL RESEARCH | 1998年 / 28卷 / 06期

关键词：

glutathione S-transferases; hydroxynonenal; base-propenals; catecholamines; oxygen radicals;

D O I：

10.3109/10715769809065820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper describes the intervention of glutathione-dependent enzymes, in particular the glutathione S-transferases (GSTs), in both the detoxication of electrophilic decomposition products resulting from the attack of oxygen radicals on lipids and DNA; and the prevention of oxygen toxicity generated by redox cycling catecholamine derivatives. The continuing growth of our knowledge of the glutathione S-transferase polygene family is described in terms of the increase in members of known gene families, the discovery of new ones and our increasing knowledge of their activities towards endogenous substrates.

引用

页码：647 / 658

页数：12

共 69 条

[11]

Board PG, 1997, BIOCHEM J, V328, P929

[12]

BOARD PG, 1998, IN PRESS BIOCH J

[13] CYTOTOXICITY, DNA FRAGMENTATION AND SISTER-CHROMATID EXCHANGE IN CHINESE-HAMSTER OVARY CELLS EXPOSED TO THE LIPID-PEROXIDATION PRODUCT 4-HYDROXYNONENAL AND HOMOLOGOUS ALDEHYDES [J].