Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology

被引：269

作者：

Wildiers, Hans ^{[1
]}

Kunkler, Ian ^{[2
]}

Biganzoli, Laura ^{[3
]}

Fracheboud, Jacques ^{[4
]}

Vlastors, George ^{[5
]}

Bernard-Marty, Chantal ^{[6
]}

Hurria, Arti ^{[7
]}

Extermann, Martine ^{[8
]}

Girre, Veronique ^{[9
]}

Brain, Etienne ^{[10
]}

Audisio, Riccardo A. ^{[11
]}

Bartelink, Harry ^{[12
]}

Barton, Mary ^{[13
]}

Giordano, Sharon H. ^{[14
]}

Muss, Hyman ^{[15
,16
]}

Aapro, Matti ^{[17
]}

机构：

[1] Univ Hosp Gasthuisberg, Dept Gen Med Oncol, B-3000 Louvain, Belgium

[2] Univ Edinburgh, Edinburgh Canc Ctr, Edinburgh, Midlothian, Scotland

[3] Hosp Prato, Ist Toscano Tumori, Sandro Pitigliani Med Oncol Unit, Prato, Italy

[4] Erasmus Univ, Med Ctr, Dept Publ Hlth, Rotterdam, Netherlands

[5] Geneva Univ Hosp, Senol & Surg Gynecol Unit, Geneva, Switzerland

[6] Univ Libre Bruxelles, Inst Jules Bordet, Med Oncol Clin, Brussels, Belgium

[7] City Hope Natl Med Ctr, Div Med Oncol & Expt Therapeut, Duarte, CA 91010 USA

[8] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA

[9] Inst Curie, Dept Med Oncol, Paris, France

[10] Rene Huguenin Canc Ctr, St Cloud, France

[11] Univ Liverpool, Whiston Hosp, Prescot, England

[12] Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands

[13] Agcy Healthcare Res & Qual, Rockville, MD USA

[14] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX USA

[15] Univ Vermont, Hematol Oncol Unit, Burlington, VT USA

[16] Vermont Canc Ctr, Burlington, VT USA

[17] Inst Multidisciplinaire Oncol, Clin Genolier, Genolier, Switzerland

来源：

LANCET ONCOLOGY | 2007年 / 8卷 / 12期

关键词：

D O I：

10.1016/S1470-2045(07)70378-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality in women worldwide. Elderly individuals make up a large part of the breast cancer population, and there are important specific considerations for this population. The international Society of Geriatric Oncology created a task force to assess the available evidence on breast cancer in elderly individuals, and to provide evidence-based recommendations for the diagnosis and treatment of breast cancer in such individuals. A review of the published work was done with the results of a search on Medline for English-language articles published between 1990 and 2007 and of abstracts from key international conferences. Recommendations are given on the topics of screening, surgery, radiotherapy, (neo)adjuvant hormone treatment and chemotherapy, and metastatic disease. Since large randomised trials in elderly patients with breast cancer are scarce, there is little level I evidence for the treatment of such patients. The available evidence was reviewed and synthesised to provide consensus recommendations regarding the care of breast cancer in older adults.

引用

页码：1101 / 1115

页数：15

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