A general strategy for the diastereoselective synthesis of 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans

被引：23

作者：

Aldous, DJ

Dalençon, AJ

Steel, PG

机构：

[1] Univ Durham, Dept Chem, Durham DH1 3LE, England

[2] Aventis Pharma Inc, Bridgewater, NJ 08807 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 23期

关键词：

D O I：

10.1021/jo035148q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy for the stereoselective synthesis of all the possible diastereoisomers of the 2,6-diaryl-3,7-dioxabicyclo-[3.3.0] octane (filrofuran) lignans from a single dihydrofuran precursor is described. The key steps involve a diastereo-controlled templated cationic cyclization followed by stereoselective reduction of the resulting methyl glycoside.

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收藏

页码：9159 / 9161

页数：3

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