A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes

被引：104

作者：

Shin, MS ^{[1
]}

Kang, EH ^{[1
]}

Lee, YI ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Biosci Res Div, Liver Cell Signal Transduct Lab, Taejon 305606, South Korea

来源：

ANTIVIRAL RESEARCH | 2005年 / 67卷 / 03期

关键词：

hepatitis B virus-e antigen; Phyllanthus urinaria; NMR spectrometer; HBeAg secretion;

D O I：

10.1016/j.antiviral.2005.06.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A flavonoid molecule that showed a unique anti-HBV function was isolated from Phyllanthus urinaria. The molecular formula was determined as C14H6O8 based on FAM-MS analysis and the structure was determined by NMR. The identified flavonoid molecule, ellagic acid, showed unique anti-HBV functions. Ellagic acid did not inhibit either HBV polymerase activity, HBV replication or block HBsAg secretion. Rather, ellagic acid blocks effectively HBeAg secretion in HepG2 2.2.15 cells (IC50 = 0.07 mu g/ml). Since HBeAg is involved in immune tolerance during HBV infection, ellagic acid, a newly identified functional anti-HBV compound, may be a new candidate therapeutic against immune tolerance in HBV-infected individuals. (C) 2005 Published by Elsevier B.V.

引用

页码：163 / 168

页数：6

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