The molecular basis of hepatitis B e antigen (HBeAg)-negative infections

被引：39

作者：

Miyakawa, Y

Okamoto, H

Mayumi, M

机构：

[1] JICHI MED SCH, DIV IMMUNOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[2] MIYAKAWA MEM RES FDN, TOKYO, JAPAN

来源：

JOURNAL OF VIRAL HEPATITIS | 1997年 / 4卷 / 01期

关键词：

hepatitis B virus; HBeAg; transcription; translation; promoter regions; fulminant hepatitis;

D O I：

10.1046/j.1365-2893.1997.00101.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis B e antigen (HBeAg)-negative infections are an unusual form of chronic hepatitis B virus (HBV) infection in which viral replication and liver damage persist despite antibodies against HBeAg. This form of HBV may be associated with fulminant hepatitis. The molecular basis for an HBeAg-minus phenotype has been extensively studied and is most often a result of mutations in the precore region. However, other mutations can give rise to this phenotype and their investigation and characterization may reveal new insights into the pathogenesis of chronic viral hepatitis.

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页码：1 / 8

页数：8

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