Factors Affecting Trypanosome Maturation in Tsetse Flies

被引：33

作者：

Macleod, Ewan Thomas ^{[1
]}

Darby, Alistair Charles ^{[1
]}

Maudlin, Ian ^{[1
]}

Welburn, Sue Christina ^{[1
]}

机构：

[1] Univ Edinburgh, Ctr Infect Dis, Coll Med & Vet Med, Easter Bush Vet Ctr, Roslin, Midlothian, Scotland

来源：

PLOS ONE | 2007年 / 2卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1371/journal.pone.0000239

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trypanosoma brucei brucei infections which establish successfully in the tsetse fly midgut may subsequently mature into mammalian infective trypanosomes in the salivary glands. This maturation is not automatic and the control of these events is complex. Utilising direct in vivo feeding experiments, we report maturation of T. b. brucei infections in tsetse is regulated by antioxidants as well as environmental stimuli. Dissection of the maturation process provides opportunities to develop transmission blocking vaccines for trypanosomiasis. The present work suggests L-cysteine and/or nitric oxide are necessary for the differentiation of trypanosome midgut infections in tsetse.

引用

页数：5

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