[alpha]-Anellated carbazoles with antitumor activity: Synthesis and cytotoxicity

被引：13

作者：

Rogge, M ^{[1
]}

Fischer, G ^{[1
]}

Pindur, U ^{[1
]}

Schollmeyer, D ^{[1
]}

机构：

[1] UNIV MAINZ,INST ORGAN CHEM,D-55099 MAINZ,GERMANY

来源：

MONATSHEFTE FUR CHEMIE | 1996年 / 127卷 / 01期

关键词：

3-vinylindoles; carbazoles; Diels-Alder reactions; cytotoxicity;

D O I：

10.1007/BF00807414

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cycloadducts 3, 5, and 7, readily available from methoxy-substituted 3-vinylindoles 1 and 2, were dehydrogenated with DDQ to the coplanar [a]-anellated carbazoles 4, 6, and 8. Compound 4a, also characterized by X-ray structural analysis, shows significant cytotoxicity against K562 und RXF393 human tumor cell lines.

引用

页码：97 / 102

页数：6

共 22 条

[11]

PINDUR U, 1990, CHIMIA, V44, P406

[12] ANTITUMOR ACTIVE-DRUGS AS INTERCALATORS OF DEOXYRIBONUCLEIC-ACID - MOLECULAR-MODELS OF INTERCALATION COMPLEXES [J].