Palladium-Catalyzed Carbonylative Heck-Type Reactions of Alkyl Iodides

被引：99

作者：

Bloome, Kayla S. ^{[1
]}

Alexanian, Erik J. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 37期

关键词：

OXIDATIVE-ADDITION; COUPLING REACTIONS; BOND FORMATION; HALIDES; COMPLEXES; DERIVATIVES; CYCLIZATION; BROMIDES;

D O I：

10.1021/ja1053913

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed carbonylative Heck-type cyclization of alkyl halides is described. Treatment of a range of primary and secondary alkyl iodides with catalytic palladium(0) under CO pressure forms a variety of synthetically versatile enone products. The reactivity described represents a rare example of a palladium-catalyzed Heck-type cyclization involving unactivated alkyl halides with beta-hydrogens. Alkene substitution is well tolerated, and mono- and bicyclic carbocycles may be easily accessed.

引用

页码：12823 / 12825

页数：3

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