Tackling the epigenome: challenges and opportunities for collaboration

被引:51
作者
Satterlee, John S. [1 ]
Schuebeler, Dirk [2 ]
Ng, Huck-Hui [3 ]
机构
[1] US Natl Inst Drug Abuse, Bethesda, MD USA
[2] Friedrich Miescher Inst, CH-4002 Basel, Switzerland
[3] Genome Inst Singapore, Singapore, Singapore
关键词
EMBRYONIC STEM-CELLS; DNA METHYLATION; HUMAN GENOME; DIFFERENTIATED CELLS; CHROMATIN; CANCER; EPIGENETICS; REVEALS; PLURIPOTENT; THERAPY;
D O I
10.1038/nbt1010-1039
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
What are the key considerations to take into account when large-scale epigenomics projects are being implemented?
引用
收藏
页码:1039 / 1044
页数:6
相关论文
共 63 条
  • [1] Brief report: Targeted therapy for inherited GPI deficiency.
    Almeida, Antonio M.
    Murakami, Yoshiko
    Baker, Alastair
    Maeda, Yusuke
    Roberts, Irene A. G.
    Kinoshita, Taroh
    Layton, D. Mark
    Karadimitris, Anastasios
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (16) : 1641 - 1647
  • [2] Genetic Mapping in Human Disease
    Altshuler, David
    Daly, Mark J.
    Lander, Eric S.
    [J]. SCIENCE, 2008, 322 (5903) : 881 - 888
  • [3] Hunting for the 5th base: Techniques for analyzing DNA methylation
    Ammerpohl, Ole
    Martin-Subero, Jose I.
    Richter, Julia
    Vater, Inga
    Siebert, Reiner
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (09): : 847 - 862
  • [4] Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
    Ball, Madeleine P.
    Li, Jin Billy
    Gao, Yuan
    Lee, Je-Hyuk
    LeProust, Emily M.
    Park, In-Hyun
    Xie, Bin
    Daley, George Q.
    Church, George M.
    [J]. NATURE BIOTECHNOLOGY, 2009, 27 (04) : 361 - 368
  • [5] Chromatin poises miRNA- and protein-coding genes for expression
    Barski, Artem
    Jothi, Raja
    Cuddapah, Suresh
    Cui, Kairong
    Roh, Tae-Young
    Schones, Dustin E.
    Zhao, Keji
    [J]. GENOME RESEARCH, 2009, 19 (10) : 1742 - 1751
  • [6] High-resolution profiling of histone methylations in the human genome
    Barski, Artern
    Cuddapah, Suresh
    Cui, Kairong
    Roh, Tae-Young
    Schones, Dustin E.
    Wang, Zhibin
    Wei, Gang
    Chepelev, Iouri
    Zhao, Keji
    [J]. CELL, 2007, 129 (04) : 823 - 837
  • [7] The methylome: approaches for global DNA methylation profiling
    Beck, Stephan
    Rakyan, Vardhman K.
    [J]. TRENDS IN GENETICS, 2008, 24 (05) : 231 - 237
  • [8] Accurate whole human genome sequencing using reversible terminator chemistry
    Bentley, David R.
    Balasubramanian, Shankar
    Swerdlow, Harold P.
    Smith, Geoffrey P.
    Milton, John
    Brown, Clive G.
    Hall, Kevin P.
    Evers, Dirk J.
    Barnes, Colin L.
    Bignell, Helen R.
    Boutell, Jonathan M.
    Bryant, Jason
    Carter, Richard J.
    Cheetham, R. Keira
    Cox, Anthony J.
    Ellis, Darren J.
    Flatbush, Michael R.
    Gormley, Niall A.
    Humphray, Sean J.
    Irving, Leslie J.
    Karbelashvili, Mirian S.
    Kirk, Scott M.
    Li, Heng
    Liu, Xiaohai
    Maisinger, Klaus S.
    Murray, Lisa J.
    Obradovic, Bojan
    Ost, Tobias
    Parkinson, Michael L.
    Pratt, Mark R.
    Rasolonjatovo, Isabelle M. J.
    Reed, Mark T.
    Rigatti, Roberto
    Rodighiero, Chiara
    Ross, Mark T.
    Sabot, Andrea
    Sankar, Subramanian V.
    Scally, Aylwyn
    Schroth, Gary P.
    Smith, Mark E.
    Smith, Vincent P.
    Spiridou, Anastassia
    Torrance, Peta E.
    Tzonev, Svilen S.
    Vermaas, Eric H.
    Walter, Klaudia
    Wu, Xiaolin
    Zhang, Lu
    Alam, Mohammed D.
    Anastasi, Carole
    [J]. NATURE, 2008, 456 (7218) : 53 - 59
  • [9] An operational definition of epigenetics
    Berger, Shelley L.
    Kouzarides, Tony
    Shiekhattar, Ramin
    Shilatifard, Ali
    [J]. GENES & DEVELOPMENT, 2009, 23 (07) : 781 - 783
  • [10] A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    Bernstein, BE
    Mikkelsen, TS
    Xie, XH
    Kamal, M
    Huebert, DJ
    Cuff, J
    Fry, B
    Meissner, A
    Wernig, M
    Plath, K
    Jaenisch, R
    Wagschal, A
    Feil, R
    Schreiber, SL
    Lander, ES
    [J]. CELL, 2006, 125 (02) : 315 - 326