Cytokine signaling to the cell cycle

被引:14
作者
Quelle, Frederick W. [1 ]
机构
[1] Univ Iowa, Grad Program Immunol, Dept Pharmacol, Iowa City, IA 52242 USA
关键词
cytokine; cytokine receptor; signal transduction; cell cycle;
D O I
10.1007/s12026-007-0080-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The proliferation of many myeloid and lymphoid cell populations is directly controlled by cytokine growth factors acting through a related family of cytokine receptors. This regulation implies that the signaling pathways activated by cytokine receptors must communicate with mechanisms that control mammalian cell cycle progression. Evidence for how these signaling pathways promote hematopoietic cell proliferation is considered along with their likely targets among the cell cycle regulators.
引用
收藏
页码:173 / 184
页数:12
相关论文
共 105 条
[1]   Forkhead transcription factors contribute to execution of the mitotic programme in mammals [J].
Alvarez, B ;
Martinez, C ;
Burgering, BMT ;
Carrera, AC .
NATURE, 2001, 413 (6857) :744-747
[2]   REGULATION OF G(1)/S TRANSITION BY CYCLIN-D2 AND CYCLIN-D3 IN HEMATOPOIETIC-CELLS [J].
ANDO, K ;
AJCHENBAUMCYMBALISTA, F ;
GRIFFIN, JD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9571-9575
[3]   Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells) [J].
Bao, HF ;
Jacobs-Helber, SM ;
Lawson, AE ;
Penta, K ;
Wickrema, A ;
Sawyer, ST .
BLOOD, 1999, 93 (11) :3757-3773
[4]   Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells [J].
Barata, JT ;
Silva, A ;
Brandao, JG ;
Nadler, LM ;
Cardoso, AA ;
Boussiotis, VA .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (05) :659-669
[5]   Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells [J].
Blalock, WL ;
Moye, PW ;
Chang, F ;
Pearce, M ;
Steelman, LS ;
McMahon, M ;
McCubrey, JA .
LEUKEMIA, 2000, 14 (06) :1080-1096
[6]   Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation [J].
Bouscary, D ;
Pene, F ;
Claessens, YE ;
Muller, O ;
Chrétien, S ;
Fontenay-Roupie, M ;
Gisselbrecht, S ;
Mayeux, P ;
Lacombe, C .
BLOOD, 2003, 101 (09) :3436-3443
[7]   PKB binding proteins: Getting in on the akt [J].
Brazil, DP ;
Park, J ;
Hemmings, BA .
CELL, 2002, 111 (03) :293-303
[8]  
Brennan P, 1999, MOL CELL BIOL, V19, P4729
[9]   Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F [J].
Brennan, P ;
Babbage, JW ;
Burgering, BMT ;
Groner, B ;
Reif, K ;
Cantrell, DA .
IMMUNITY, 1997, 7 (05) :679-689
[10]   Stat3 as an oncogene [J].
Bromberg, JF ;
Wrzeszczynska, MH ;
Devgan, G ;
Zhao, YX ;
Pestell, RG ;
Albanese, C ;
Darnell, JE .
CELL, 1999, 98 (03) :295-303