Spliceosomal UsnRNP biogenesis, structure and function

被引:530
作者
Will, CL [1 ]
Lührmann, R [1 ]
机构
[1] Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
关键词
D O I
10.1016/S0955-0674(00)00211-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6 . U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.
引用
收藏
页码:290 / 301
页数:12
相关论文
共 88 条
  • [71] Highly diverged U4 and U6 small nuclear RNAs required for splicing rare AT-AC introns
    Tarn, WY
    Steitz, JA
    [J]. SCIENCE, 1996, 273 (5283) : 1824 - 1832
  • [72] Teigelkamp S, 1998, RNA, V4, P127
  • [73] Yeast Sm-like proteins function in mRNA decapping and decay
    Tharun, S
    He, WH
    Mayes, AE
    Lennertz, P
    Beggs, JD
    Parker, R
    [J]. NATURE, 2000, 404 (6777) : 515 - 518
  • [74] Function and synthesis of small nucleolar RNAs
    Tollervey, D
    Kiss, T
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1997, 9 (03) : 337 - 342
  • [75] Modification of U6 spliceosomal RNA is guided by other small RNAs
    Tycowski, KT
    You, ZH
    Graham, PJ
    Steitz, JA
    [J]. MOLECULAR CELL, 1998, 2 (05) : 629 - 638
  • [76] Umen JG, 1995, RNA, V1, P869
  • [77] Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure
    Urlaub, H
    Raker, VA
    Kostka, S
    Lührmann, R
    [J]. EMBO JOURNAL, 2001, 20 (1-2) : 187 - 196
  • [78] Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
    Van Hoof, A
    Lennertz, P
    Parker, R
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (02) : 441 - 452
  • [79] Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast
    van Hoof, A
    Lennertz, P
    Parker, R
    [J]. EMBO JOURNAL, 2000, 19 (06) : 1357 - 1365
  • [80] Characterization of U6 snRNA-protein interactions
    Vidal, VPI
    Verdone, L
    Mayes, AE
    Beggs, JD
    [J]. RNA, 1999, 5 (11) : 1470 - 1481