Antioxidant and neuroprotective properties of N-arachidonoyldopamine

被引：40

作者：

Bobrov, Mikhail Yu. ^{[1
]}

Lizhin, Anatoly A. ^{[2
]}

Andrianova, Ekaterina L. ^{[1
]}

Gretskaya, Natalia M. ^{[1
]}

Frumkina, Lidia E. ^{[2
]}

Khaspekov, Leonid G. ^{[2
]}

Bezuglov, Vladimir V. ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Biorgan Chem, Oxylipin Lab, Moscow 117997, Russia

[2] Russian Acad Sci, Ctr Neurol Sci, Moscow, Russia

来源：

NEUROSCIENCE LETTERS | 2008年 / 431卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

N-arachidonoyldopamine; N-acyldopamine; cannabinoid; vanilloid; antioxidant; neuroprotection;

D O I：

10.1016/j.neulet.2007.11.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

N-Acyldopamines were recently described as putative endogenous substances in the rat brain. Among them, N-arachidonoyldopamine (AADA) was characterized as cannabinoid CBI and vanilloid TRPV1 receptor ligand. The physiological significance of such compounds is yet poorly understood. In this study, we describe the novel properties of AADA as antioxidant and neuroprotectant. Antioxidant potential of AADA and its analogs were first tested in the galvinoxyl assay. It was found that N-acyldopamines are potent antioxidants and that the number of free hydroxyl groups in the phenolic moiety of dopamine is essential for the activity. AADA dose dependently (0.1-10 mu M) protected cultured cerebellar granule neurons (CGN) in the model of oxidative stress induced by hydrogen peroxide. N-Oleoyldopamine, another endogenous substance, was much less potent in these conditions while the natural antioxidant a-tocopherol was inactive. In this test, AADA decreased the peroxide level in CGN preparations and its neuroprotection was independent of cannabinoid/vanilloid receptors blockade. AADA (10 mu M) also protected CGN from death induced by K+/serum deprivation and glutamate exitotoxicity. These data indicate that AADA may act as endogenous antioxidant in different pathological conditions. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：6 / 11

页数：6

共 29 条

[21] N-docosahexaenoyl, 3 hydroxytyramine: A dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite [J].

Shashoua, VE ;

Hesse, GW .

LIFE SCIENCES, 1996, 58 (16) :1347-1357

[22] Stoichiometric and kinetic studies on Ginkgo biloba extract and related antioxidants [J].

Shi, HL ;

Niki, E .

LIPIDS, 1998, 33 (04) :365-370

[23] Neuronal Death/Survival Signaling Pathways in Cerebral Ischemia [J].

Sugawara T. ;

Fujimura M. ;

Noshita N. ;

Kim G.W. ;

Saito A. ;

Hayashi T. ;

Narasimhan P. ;

Maier C.M. ;

Chan P.H. .

NeuroRX, 2004, 1 (1) :17-25

[24] Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat [J].

Tóth, A ;

Kedei, N ;

Wang, Y ;

Blumberg, PM .

LIFE SCIENCES, 2003, 73 (04) :487-498

[25] INHIBITION OF INVITRO PROSTAGLANDIN AND LEUKOTRIENE BIOSYNTHESES BY CINNAMOYL-BETA-PHENETHYLAMINE AND N-ACYLDOPAMINE DERIVATIVES [J].

TSENG, CF ;

IWAKAMI, S ;

MIKAJIRI, A ;

SHIBUYA, M ;

HANAOKA, F ;

EBIZUKA, Y ;

PADMAWINATA, K ;

SANKAWA, U .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1992, 40 (02) :396-400

[26] Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons [J].

Valencia, A ;

Morán, J .

JOURNAL OF NEUROSCIENCE RESEARCH, 2001, 64 (03) :284-297

[27]

Vasil'eva T. M., 2002, Eksperimental'naya i Klinicheskaya Farmakologiya, V65, P41

[28]

Veldhuis WB, 2003, J NEUROSCI, V23, P4127

[29] Antioxidant effects of dopamine and related compounds [J].

Yen, GC ;

Hsieh, CL .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1997, 61 (10) :1646-1649

← 1 2 3 →