Stereoselectivity in the double reductive alkylation of pyrroles:: synthesis of cis-3,4-disubstituted pyrrolidines

被引：10

作者：

Donohoe, TJ

Harji, RR

Cousins, RPC

机构：

[1] Univ Manchester, Dept Chem, Manchester M13 9PL, Lancs, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 02期

关键词：

D O I：

10.1039/a809193e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation and Birch reduction of a 1,3,4-tri-substituted pyrrole is described: the heterocycle is loaded with electron-withdrawing groups and undergoes a double reductive alkylation reaction to yield cis-3,4-disubstituted pyrrolidines.

引用

页码：141 / 142

页数：2

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